ABCB11 Antibody
Rabbit Polyclonal
Catalog number: 18990-1-AP
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Applications
| Tested applications | ELISA |
| Cited applications | |
| Species specificity | human, mouse; other species not tested. |
| Cited species |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
|
Calculated molecular weight |
146kd |
Observed molecular
weight |
|
|
GenBank accession number |
NM_003742 | Gene ID (NCBI) | 8647 |
| Gene symbol | ABCB11 | Synonyms | ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP |
Background
ABCB11, also named as BSEP, belongs to the ABC transporter superfamily. ABCB11 involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Mutation of ABCB11 will cause the progressive familial intrahepatic cholestasis type 2 (PFIC2) and the benign recurrent intrahepatic cholestasis type 2 (BRIC2). Genetic variations in ABCB11 may play a role in drug-induced cholestasis causing liver damage. |
