ABCB11 Antibody
Rabbit PolyClonal
Catalog No.: 18990-1-AP
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Applications
| Tested Applications: | ELISA |
| Specificity Reaction: | Human, Mouse; Other species are not tested.Please decide the specificity by homology |
Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Product Information
| Source: | Rabbit | Purify: | Antigen Affinity purified |
| IsoType: | IgG | Storage: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles. |
Immunogen Information
| Immunogen: | Peptide | Full Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
|
Caculated Molecular Weight: |
146kd |
Observed Molecular
Weight: |
|
| GenbankNo | NM_003742 | GeneID: | 8647 |
| Symbol | ABCB11 | Synonyms | ABCB11;ABC16;BRIC2;BSEP;PFIC-2;PFIC2;PGY4;SPGP ; |
Background
ABCB11, also named as BSEP, belongs to the ABC transporter superfamily. ABCB11 involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Mutation of ABCB11 will cause the progressive familial intrahepatic cholestasis type 2 (PFIC2) and the benign recurrent intrahepatic cholestasis type 2 (BRIC2). Genetic variations in ABCB11 may play a role in drug-induced cholestasis causing liver damage. |
