BCL6 Antibody
Mouse Monoclonal
Catalog number: 60184-1-Ig
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Applications
| Tested applications | ELISA, WB |
| Cited applications | |
| Species specificity | human; other species not tested. |
| Cited species | |
| Positive WB detected in | Raji cell |
| Recommended dilution | WB: 1:200-1:1000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Raji cell were subjected to SDS PAGE followed by western blot with 60184-1-Ig(BCL6 Antibody) at dilution of 1:400
Product Information
| Source | Mouse | Purification method | Protein A purification |
| Isotype | IgG2a | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | BCL6 fusion protein ag15519 | Full name | B-cell CLL/lymphoma 6 |
|
Calculated molecular weight |
706aa,79kd |
Observed molecular
weight |
79kd |
|
GenBank accession number |
BC150184 | Gene ID (NCBI) | 604 |
| Gene symbol | BCL6 | Synonyms | BCL5; BCL6A; LAZ3; ZBTB27; ZNF51 |
Background
BCL6 is a transcription factor that has essential B-cell and T-cell roles in normal antibody responses. It is a zinc-finger transcriptional repressor that is essential for the germinal center (GC) reaction of lymph nodes, protecting germinal center (GC) B cells against DNA damage-induced apoptosis during somatic hypermutation and class-switch recombination. BCL6 is also a frequently activated oncogene in the pathogenesis of human B cell lymphomas, most of which derive from the GC B cells. |
