CCND2 Antibody
Rabbit Polyclonal
Catalog number: 10934-1-AP
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Applications
| Tested applications | ELISA, IHC, IF |
| Cited applications | IF, IHC, WB |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive IHC detected in | human gliomas |
| Positive IF detected in | SH-SY5Y cells |
| Recommended dilution | IHC: 1:20-1:200 IF: 1:20-1:100 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Immunohistochemistry of paraffin-embedded human gliomas using 10934-1-AP(CCND2 Antibody) at Dilution 1:50 (under 10x lens)
Immunofluorescent analysis of SH-SY5Y cells, using CCND2 antibody 10934-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | CCND2 fusion protein ag1377 | Full name | cyclin D2 |
|
Calculated molecular weight |
32kd |
Observed molecular
weight |
|
|
GenBank accession number |
BC010958 | Gene ID (NCBI) | 894 |
| Gene symbol | CCND2 | Synonyms | KIAK0002; MGC102758 |
Background
CCND2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. CCND2 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. High level expression of CCND2 was observed in ovarian and testicular tumors. |
