FBLN5 Antibody
Mouse Monoclonal
Catalog number: 65018-1-Ig
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IF |
| Species specificity | human, mouse; other species not tested. |
| Cited species | human |
| Positive WB detected in | Hela cells |
| Positive IHC detected in | Breast cancer |
| Recommended dilution | WB: 1:500-1:5000 IHC: 1:50-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Hela cells were subjected to SDS PAGE followed by western blot with 65018-1-Ig(FBLN5 Antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded Breast cancer using 65018-1-Ig(FBLN5 Antibody) at Dilution 1:100
Product Information
| Source | Mouse | Purification method | Protein A purification |
| Isotype | IgG1 | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Recombinant Protein | Full name | fibulin 5 |
|
Calculated molecular weight |
448aa,50kd |
Observed molecular
weight |
50KD |
|
GenBank accession number |
BC022280 | Gene ID (NCBI) | 10516 |
| Gene symbol | FBLN5 | Synonyms | ARMD3; DANCE; EVEC; FIBL-5; FLJ90059; UP50 |
Background
Fibulin-5, also known as EVEC and DANCE, is a extracellular matrix glycoprotein, secreted by various cell types such as vascular smooth muscle cells, fibroblasts and endothelial cells. Structurally, Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies. |
