Mcl-1l-specific Antibody
Rabbit Polyclonal
Catalog number: 15824-1-AP
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Applications
| Tested applications | ELISA |
| Cited applications | |
| Species specificity | human, mouse; other species not tested. |
| Cited species |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | myeloid cell leukemia sequence 1 (BCL2-related) |
|
Calculated molecular weight |
37kd |
Observed molecular
weight |
|
|
GenBank accession number |
NM_021960 | Gene ID (NCBI) | 4170 |
| Gene symbol | MCL1 | Synonyms | BCL2L3; EAT; MCL1L; MCL1S; MGC104264; MGC1839; Mcl-1; TM |
Background
MCL1 is a potent multidomain antiapoptotic protein belonging to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1, 37-40kd) enhances cell survival by inhibiting apoptosis, while the alternatively spliced shorter gene product (isoform 2, 29-32kd) promotes apoptosis and is death-inducing. This antibody is specific to long isoform of MCL protein. |
