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NRG4 Polyclonal antibody

NRG4 Polyclonal Antibody for IHC,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

IHC,ELISA

Conjugate

Unconjugated

Cat no : 11206-1-AP

Synonyms

HRG4, neuregulin 4, NRG 4, NRG4, Pro NRG4

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human breast cancer tissue using NRG4 Polyclonal antibody (11206-1-AP)

    IHC staining of human breast cancer using 11206-1-AP

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11206-1-AP (NRG4 Antibody) at dilution of 1:50 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using NRG4 Polyclonal antibody (11206-1-AP)

    IHC staining of human breast cancer using 11206-1-AP

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11206-1-AP (NRG4 Antibody) at dilution of 1:50 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human prostate cancer tissue using NRG4 Polyclonal antibody (11206-1-AP)

    IHC staining of human prostate cancer using 11206-1-AP

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 11206-1-AP (NRG4 Antibody) at dilution of 1:50 (under 10x lens).

  • Immunohistochemistry (IHC) staining of human prostate cancer tissue using NRG4 Polyclonal antibody (11206-1-AP)

    IHC staining of human prostate cancer using 11206-1-AP

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 11206-1-AP (NRG4 Antibody) at dilution of 1:50 (under 40x lens).

  • Immunohistochemistry (IHC) staining of human ovary tumor tissue using NRG4 Polyclonal antibody (11206-1-AP)

    IHC staining of human ovary tumor using 11206-1-AP

    Immunohistochemical analysis of paraffin-embedded human ovary tumor using 11206-1-AP (NRG4 antibody) at dilution of 1:50 (under 40x lens).

Tested Applications

Positive IHC detected inhuman breast cancer tissue, human ovary tumor tissue, human prostate cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11206-1-AP targets NRG4 in IHC,ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NRG4 fusion protein Ag1697
Full Name neuregulin 4
Calculated Molecular Weight 13 kDa
GenBank Accession NumberBC017568
Gene Symbol NRG4
Gene ID (NCBI) 145957
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, is expressed in multiple organs with the highest expression levels in brown adipose tissue. Neuregulin 4 is a secreted adipokine recently identified as playing an important role in modulating systemic energy metabolism and in the development of metabolic disorders in rodent and human obesity, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Nrg4 attenuates hepatic lipogenic signaling and preserves glucose and lipid homeostasis in obesity.