POLA1 Antibody
Rabbit Polyclonal
Catalog number: 19711-1-AP
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Applications
| Tested applications | ELISA |
| Cited applications | |
| Species specificity | human; other species not tested. |
| Cited species |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | Peptide | Full name | polymerase (DNA directed), alpha 1, catalytic subunit |
|
Calculated molecular weight |
166kd |
Observed molecular
weight |
|
|
GenBank accession number |
NM_016937 | Gene ID (NCBI) | 5422 |
| Gene symbol | POLA1 | Synonyms | DKFZp686K1672; POLA; p180 |
Background
POLA1, also named as Pola, belongs to the DNA polymerase type-B family. POLA1 plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. |
