PSMB9 Antibody
Rabbit Polyclonal
Catalog number: 14544-1-AP
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Applications
| Tested applications | ELISA, WB, IHC |
| Cited applications | IF, IHC |
| Species specificity | human, mouse, rat; other species not tested. |
| Cited species | human |
| Positive WB detected in | Raji cells, HepG2 cells |
| Positive IHC detected in | human lymphoma |
| Recommended dilution | WB: 1:200-1:2000 IHC: 1:20-1:200 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
Raji cells were subjected to SDS PAGE followed by western blot with 14544-1-AP(PSMB9 Antibody) at dilution of 1:800
Immunohistochemistry of paraffin-embedded human lymphoma using 14544-1-AP(PSMB9 Antibody) at Dilution 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human lymphoma using 14544-1-AP(PSMB9 Antibody) at Dilution 1:50 (under 40x lens)
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | PSMB9 fusion protein ag6048 | Full name | proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) |
|
Calculated molecular weight |
23kd |
Observed molecular
weight |
21-23kd |
|
GenBank accession number |
BC065513 | Gene ID (NCBI) | 5698 |
| Gene symbol | PSMB9 | Synonyms | LMP2; MGC70470; PSMB6i; RING12; beta1i |
Background
PSMB9, also named as LMP2, PSMB6i and RING12, belongs to the peptidase T1B family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. High expression of PSMB9 associated with the poor prognosis of patients with NPC. |
