RAB23 Antibody
Mouse Monoclonal
Catalog number: 60056-1-Ig
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Applications
| Tested applications | ELISA, WB |
| Cited applications | |
| Species specificity | human, mouse; other species not tested. |
| Cited species | |
| Positive WB detected in | HEK-293 cells, HeLa cells, human brain tissue |
| Recommended dilution | WB: 1:500-1:5000 |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Images
HEK-293 cells were subjected to SDS PAGE followed by western blot with 60056-1-Ig(RAB23 Antibody) at dilution of 1:1000
Product Information
| Source | Mouse | Purification method | Protein G Purified |
| Isotype | IgG1 | Storage | PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | RAB23 fusion protein ag1588 | Full name | RAB23, member RAS oncogene family |
|
Calculated molecular weight |
237aa,27kd |
Observed molecular
weight |
27-30kd |
|
GenBank accession number |
BC015021 | Gene ID (NCBI) | 51715 |
| Gene symbol | RAB23 | Synonyms | DKFZp781H0695; HSPC137; MGC8900 |
Background
Rab23 is a novel member of large Rab small GTPase family. It plays important roles during embryonic development. The brain-enriched Rab23 is the only Rab protein that is known to have a distinct function during central nervous system development, playing an essential role as a negative regulator of the Sonic Hedgehog (Shh) pathway. RAB23 has recently been identified in mesangial cells (MCs), and could serve as a biomarker that indicates the severity of FSGS ( focal segmental glomerulosclerosis). Mutations in RAB23 may result in ACPS2 ( acrocephalopolysyndactyly type 2). |
