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UBE2W Polyclonal antibody
UBE2W Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
WB, IF, ELISA
Conjugate
Unconjugated
Cat no : 15920-1-AP
Synonyms
Validation Data Gallery
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 2 publications below |
| WB | See 2 publications below |
| IF | See 1 publications below |
Product Information
15920-1-AP targets UBE2W in WB, IF, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | UBE2W fusion protein Ag8729 |
| Full Name | ubiquitin-conjugating enzyme E2W (putative) |
| Calculated Molecular Weight | 159 aa, 18 kDa |
| GenBank Accession Number | BC010900 |
| Gene Symbol | UBE2W |
| Gene ID (NCBI) | 55284 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
UBE2W(Ubiquitin-conjugating enzyme E2 W) is also named as UBC16. The deduced 162-amino acid protein has an approximately 150-amino acid catalytic core, termed the E2 ubiquitin-conjugating enzyme (UBC) domain, which contains 2 nuclear localization signals at its C-terminal end. RT-PCR detected ubiquitous UBC16 expression, with highest expression in heart, brain, liver, and pancreas(PMID:16368532). Ube2w can form nuclear homodimers(PMID:21229326). It has 3 isoforms produced by alternative splicing.
Publications
| Species | Application | Title |
|---|---|---|
Neurobiol Dis The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
| ||
J Biol Chem Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
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