b-cat Antibody
Rabbit Polyclonal
Catalog number: 17565-1-AP
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Applications
| Tested applications | ELISA |
| Cited applications | |
| Species specificity | human, mouse, rat, zebrafish; other species not tested. |
| Cited species |
Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
IP = Immunoprecipitation
Product Information
| Source | Rabbit | Purification method | Antigen affinity purification |
| Isotype | IgG | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen | b-cat fusion protein ag11763 | Full name | catenin (cadherin-associated protein), beta 1, 88kDa |
|
Calculated molecular weight |
781aa,86kd |
Observed molecular
weight |
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GenBank accession number |
BC058926 | Gene ID (NCBI) | 1499 |
| Gene symbol | CTNNB1 | Synonyms | CTNNB; DKFZp686D02253; FLJ25606; FLJ37923 |
Background
β-catenin is an evolutionarily conserved, multifunctional intracellular protein. β-catenin was originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to α-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222) |
