P5CS Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 17719-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF7 cells, HeLa cells, HepG2 cells, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
aldehyde dehydrogenase 18 family, member A1

Calculated molecular weight:
795aa,87 kDa

Observed molecular weight:
87 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ALDH18A1

Synonyms
ALDH18A1, GK, GPR, GSAS, P5CS, PYCS
Background

Delta 1-pyrroline-5-carboxylate synthetase (P5CS), also named as GSAS, P5CS, PYCS, catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis(PMID:8761662). This protein includes 2 domains: glutamate 5-kinase and gamma-glutamyl phosphate reductase. In the N-terminal section, it belongs to the glutamate 5-kinase family and in the C-terminal section, it belongs to the gamma-glutamyl phosphate reductase family. Defects in ALDH18A1 are the cause of cutis laxa, autosomal recessive, type 3A (ARCL3A)(PMID:18478038). It has 2 isoforms produced by alternative splicing.


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