Amphiphysin Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 13379-1-AP

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, mouse lung tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human pancreas cancer tissue

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
amphiphysin

Calculated molecular weight:
695aa,76 kDa

Observed molecular weight:
115-125 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AMPH

Synonyms
AMPH, AMPH1, Amphiphysin
Background

Amphiphysin (AMPH), a synaptic vesicle-associated protein that is highly concentrated in nerve terminal, is an autoantigen of Stiff-Man syndrome with breast cancer. Amphiphysin contains a N-terminal BAR (Bin1/Amphiphysin/Rv167) domain followed by an endocytosis domain, and a C-terminal SH3 domain. Amphiphysin has been proposed to function as a linker between the clathrin coat and dynamin in the endocytosis of synaptic vesicles. It may also participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. (PMID: 8552632; 8245793; 10559861)


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