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ASCC1 Polyclonal antibody

ASCC1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 12301-1-AP

Synonyms

ASC 1 complex subunit p50, ASC1p50, ASCC1, CGI 18, RP11 150D20.4, Trip4 complex subunit p50

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using ASCC1 Polyclonal antibody (12301-1-AP)

    WB analysis using 12301-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 12301-1-AP (ASCC1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 3 publications below

Product Information

12301-1-AP targets ASCC1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ASCC1 fusion protein Ag2946
Full Name activating signal cointegrator 1 complex subunit 1
Calculated Molecular Weight 45.5 kDa
Observed Molecular Weight 45.5 kDa
GenBank Accession NumberBC012291
Gene Symbol ASCC1
Gene ID (NCBI) 51008
RRIDAB_2059350
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ASCC1 (also known as p50) is a subunit of an uncharacterized complex, the activating signal co-integrator complex (ASCC). ASCC1 has been reported as regulator fo NF-kB pathway and potently inhibits the expression of NF-kB target genes. Mutations in ASCC1 in patients with Barrett esophagus (BE) have been identified as a risk factor of esophageal adenocarcinoma (EAC).

Protocols

Product Specific Protocols
WB protocol for ASCC1 antibody 12301-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Nat Commun

Extended DNA threading through a dual-engine motor module of the activating signal co-integrator 1 complex

Authors - Junqiao Jia
View Article
humanWB

Mol Cell

Translation stress and collided ribosomes are co-activators of cGAS.

Authors - Li Wan
View Article
humanWB

Mol Cell

Unresolved stalled ribosome complexes restrict cell-cycle progression after genotoxic stress.

Authors - Mark Stoneley
View Article