Alpha-1-Antitrypsin Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66135-1-Ig |CloneNo.: 1A9G6

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Freight/Packing

Con: 127 μg/150 μl

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Species specificity:
human, rat

Positive WB detected in:
HepG2 cells, L02 cells, rat liver tissue

Positive IP detected in:
human plasma tissue

Positive IHC detected in:
human liver tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:5000-1:20000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:500-1:1000
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

Calculated molecular weight:
418aa,47 kDa

Observed molecular weight:
51 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SERPINA1

Synonyms
A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, α1-antitrypsin
Background

SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.


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