SURVIVIN-Specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 19119-1-AP

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Freight/Packing

Con: 57 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human colon cancer tissue, human lung cancer tissue, human pancreas cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
baculoviral IAP repeat-containing 5

Calculated molecular weight:
18 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BIRC5

Synonyms
API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN
Background

BIRC5, also named as API4 and IAP4, is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.BIRC5 may play a role in neoplasia and counteract a default induction of apoptosis in G2/M phase. The antibody can recognize all these isoforms of BIRC5.


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