BUB3 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10123-2-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive IF detected in:
HepG2

Recommended dilution:
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
budding uninhibited by benzimidazoles 3 homolog (yeast)

Calculated molecular weight:
37 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BUB3

Synonyms
BUB3, hBUB3, BUB3L
Background

BUB3 is a conserved component of the mitotic spindle assembly complex and is an essential compent of spindle-assembly checkpoint (SAC) signaling that operates during early embryogenesis. BUB3 null embryos treated with a spindle-depolymerising agent fail to arrest in metaphase and show an increase in mitotic disarray. In mitosis, the SAC prevents anaphase onset until all chromosomes have been attached to the spindle microtubules and aligned correctly at the equatorial metaphase plate. BUB3 is involved in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments in mammalian oocyte meiosis.


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