Calsequestrin 2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66419-1-Ig |CloneNo.: 1C10A1

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat, pig, mouse

Positive WB detected in:
human skeletal muscle tissue, mouse skeletal muscle tissue, rat skeletal muscle tissue

Positive IHC detected in:
human heart tissue

Recommended dilution:
WB : 1:5000-1:20000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
calsequestrin 2 (cardiac muscle)

Calculated molecular weight:
46 kDa

Observed molecular weight:
50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASQ2

Synonyms
Calsequestrin 2, CASQ2, FLJ26321, FLJ93514, PDIB2
Background

Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.


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