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Different expression of B7-H3 in the caput, corpus, and cauda of the epididymis in mouse.
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B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 belongs to the B7 immunoregulatory family and participate in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 20696859). Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063).