Cofilin Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 10960-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 20 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF-7 cells,NIH/3T3 cells, mouse brain tissue, human skin tissue, human brain tissue, rat brain tissue

Positive IHC detected in:
human cervical cancer tissue, human cervical cancer tissue, human heart tissue, human lung cancer tissue

Positive IF detected in:
NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cofilin 1 (non-muscle)

Calculated molecular weight:
18 kDa

Observed molecular weight:
18-22 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CFL1

Synonyms
18 kDa phosphoprotein, CFL, CFL1, Cofilin 1, cofilin 1 (non muscle), Cofilin, non muscle isoform, p18
Background

Cofilin is a ubiquitous actin-binding protein required for the reorganization of actin filaments. It is a member of ADF (actin-depolymerizing factor)/cofilin family that is a key regulator of actin dynamics and essential for cellular motility, cytokinesis, and endocytosis. Cofilin activity is tightly regulated by phosphorylation and dephosphorylation.Phosphorylation at Ser3 can inhibit its activity, also causing translocation from the nucleus to the cytoplasm.


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