CIRBP Antibody 32 Publications

Rabbit Polyclonal| Catalog number: 10209-2-AP

Featured Product KD/KO validated

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Con: 44 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, A549 cells

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human placenta tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cold inducible RNA binding protein

Calculated molecular weight:
172aa, 19 kDa

Observed molecular weight:
19 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CIRBP

Synonyms
A18 hnRNP, A18HNRNP, CIRBP, CIRP
Background

CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival[PMID: 19158277]. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation[PMID: 19777567]. CIRBP can translocate from nucleus to cytoplasm under stresses such as UV irradation or heat shock. Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature[PMID: 20735994]. This antibody (Catalog# 10209-2-AP) is a rabbit polyclonal antibody raised against the full-length CIRBP of human origin.


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