CIRBP Antibody 1 Publications

Mouse Monoclonal| Catalog number: 60025-2-Ig |CloneNo.: 4D12H7

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Freight/Packing

Con: 150 μg/150 μl

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Tested Applications

Applications:
ELISA, IHC
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Species specificity:
human, mouse

Recommended dilution:

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgM

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cold inducible RNA binding protein

Calculated molecular weight:
172aa, 19 kDa

Observed molecular weight:
19 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CIRBP

Synonyms
A18 hnRNP, A18HNRNP, CIRBP, CIRP
Background

CIRBP, also named as A18HNRNP and CIRP, is a cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP is also involved in cap-independent translation upon moderate cold-shock. It acts as a translational activator. CIRBP is a suppressive rather stimulatory effect on proliferation. It acts as a translational repressor. CIRBP is an immortalized gene in murine primary cells. CIRBP promotes assembly of stress granules (SGs), when overexpressed. It is a potential proto-oncogenic proteins upon overexpression.(PMID:19900510) Suppression of CIRBP increased the apoptotic cell population of neural stem cells at moderate low temperature. (PMID:20735994) This antibody can bind the close sequences genes. This antibody is a mouse monoclonal antibody raised against full length CIRBP of human origin.


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