CISD2 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 13318-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 52 μg/150 μl

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Species specificity:
human, mouse, rat, Drosophila

Positive WB detected in:
mouse kidney tissue, HeLa cells, human brain tissue, mouse brain tissue, mouse heart tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human kidney tissue, human brain tissue, human kidney tissue, human lung tissue, human ovary tissue, human pancreas tissue, human spleen tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CDGSH iron sulfur domain 2

Calculated molecular weight:
135aa,15 kDa

Observed molecular weight:
13-15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CISD2

Synonyms
CDGSH iron sulfur domain 2, CDGSH2, CISD2, ERIS, Miner1, MitoNEET related 1 protein, NAF 1, WFS2, ZCD2
Background

CISD2 gene encodes a 15 kDa CDGSH iron-sulfur domain-containing protein 2, which is also named Miner1 or NAF-1, this protein was reported on endoplasmic reticulum membrane or mitochondrion outer membrane. Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2), a rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. CISD2 regulates autophagy program by interacting BCL2, contributing to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum.


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