CLEC2D Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 13188-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
C-type lectin domain family 2, member D

Calculated molecular weight:
154aa,18 kDa

Observed molecular weight:
33 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CLEC2D

Synonyms
CLAX, CLEC2D, Lectin like NK cell receptor, Lectin like transcript 1, LLT 1, LLT1, OCIL, Osteoclast inhibitory lectin
Background

CLEC2D (C-type lectin domain family 2 member D), also known as LLT1 (lectin-like transcript 1) or OCIL (Osteoclast inhibitory lectin), is a single-pass type II membrane protein expressed by hematopoietic cells and osteoblasts (PMID: 21930700; 14753741). Its expression was found to be tightly correlated with activation on T cells, NK cells, B cells, and DCs (PMID: 21930700). CLEC2D is a ligand for the human NKR-P1A (CD161) receptor and that their interaction differentially regulates NK- and T-cell functions (PMID: 16339513, 16339512). It inhibits the formation and function of osteoclasts and modulates the release of interferon-gamma by human NK cells (PMID:14753741; 20415786).


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