Cystatin C Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12245-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human brain tissue, Caco-2 cells, fetal human brain tissue

Positive IP detected in:
Caco-2 cells

Positive IHC detected in:
human kidney tissue, human brain tissue, human kidney tissue, human ovary tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cystatin C

Calculated molecular weight:
146aa,16 kDa

Observed molecular weight:
13 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CST3

Synonyms
ARMD11, CST3, Cystatin 3, cystatin C, CYTC, Gamma trace, Post gamma globulin
Background

Cystatin C is a 13-kDa inhibitor of cysteine proteinases which is secreted by all cell types and is completely cleared from the organism through glomerular filtration, shown to be an early and sensitive biomarker of renal dysfunction. A mutation in Cystatin C has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus.


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