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The chemokine receptor CXCR4, a 7-transmembrane protein on cell surface, acts with the CD4 protein to support HIV entry into cells. CXCR4 is highly expressed in brain and heart, white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. Lots of CXCR4 isoforms have been reported: 47, 50, 62, and 98-102 kDa. The 62-kDa CXCR4 is predominantly ubiquitinated and6 preferentially associated with CD4.