DNA2 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 18727-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 43 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse thymus tissue

Positive IHC detected in:
human cervical cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
DNA replication helicase 2 homolog (yeast)

Calculated molecular weight:
120 kDa

Observed molecular weight:
127 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DNA2

Synonyms
DNA2, DNA2L, FLJ10063, KIAA0083
Background

DNA2(DNA replication ATP-dependent helicase/nuclease DNA2) is also named as DNA2L, KIAA0083 and belongs to the DNA2/NAM7 helicase family. This protein includes 2 domains: DNA replication nuclease and DNA replication ATP-dependent helicase. It is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability and it can interact with DNA polymerase gamma and stimulating its activity. It can also process intermediate 5' flap structures occuring in DNA replication long-patch base excision repair in mitochondria. It has 4 isoforms produced by alternative splicing. This antibody is specific to DNA2.


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