DOK1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 17822-1-AP

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Freight/Packing

Con: 61 μg/150 μl

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Species specificity:
human

Positive WB detected in:
K-562 cells

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Calculated molecular weight:
48aa,52 kDa

Observed molecular weight:
62 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DOK1

Synonyms
Docking protein 1, DOK1, p62(dok), P62DOK, pp62
Background

The downstream of tyrosine kinase 1gene (DOK1) has emerged as a newly identified tumor suppressor gene that encodes a multi-domain adapter protein and acts as a negative regulator of signaling pathways involved in several cellular functions. DOK1 inhibits cell proliferation, down regulates MAP kinase activity, and has an opposing role in leukemogenesis and promotes cell spreading, motility, and apoptosis. (PMID: 24809689)


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