EZH2 Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 21800-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 55 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat, pig

Positive WB detected in:
Raji cells, A431 cells, BxPC-3 cells, DU 145 cells, HEK-293 cells, HepG2 cells, Jurkat cells, mouse kidney tissue, NIH/3T3 cells, rat kidney tissue

Positive IP detected in:
HepG2 cells

Positive IF detected in:
HepG2 cells

ApplicationNote:
This antibody is not suggested for IHC test.

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
enhancer of zeste homolog 2 (Drosophila)

Calculated molecular weight:
751aa,86 kDa

Observed molecular weight:
90-102 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EZH2

Synonyms
Enhancer of zeste homolog 2, ENX 1, EZH1, EZH2, KMT6, Lysine N methyltransferase 6
Background

EZH2 (enhancer of zeste homologue 2, also known as KMT6) is a member of Polycomb group (PcG) family and encodes a histone methyl transferase that has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing. EZH2 is important for cell proliferation and inhibition of cell differentiation, and is implicated in cancer progression. Overexpression of EZH2 is a marker of advanced and metastatic disease in many solid tumors, including prostate and breast cancer. This antibody detected EZH2 protein as a single band with a molecular weight (MW) of 91-100 kDa in multiple cell lines. The phosphorylation may result in the higher molecular weight (calculated MW as 80-86 kDa). (20935635, 21367748)


Back
to top