EZH2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66476-1-Ig |CloneNo.: 1F10A12

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Con: 150 μg/150 μl

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Species specificity:
Human, mouse, rat

Positive WB detected in:
HEK-293 cells

Recommended dilution:
WB : 1:5000-1:20000

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
enhancer of zeste homolog 2 (Drosophila)

Calculated molecular weight:
751aa,86 kDa

Observed molecular weight:
85, 100 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EZH2

Synonyms
Enhancer of zeste homolog 2, ENX 1, EZH1, EZH2, KMT6, Lysine N methyltransferase 6
Background

EZH2 (enhancer of zeste homologue 2, also known as KMT6) is a member of Polycomb group (PcG) family and encodes a histone methyl transferase that has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing. EZH2 is important for cell proliferation and inhibition of cell differentiation, and is implicated in cancer progression. Overexpression of EZH2 is a marker of advanced and metastatic disease in many solid tumors, including prostate and breast cancer. This antibody detected EZH2 protein as a single band with a molecular weight (MW) of 91-100 kDa in multiple cell lines. The phosphorylation may result in the higher molecular weight (calculated MW as 80-86 kDa). (20935635, 21367748)


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