FcRn-Specific Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 16190-1-AP

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Freight/Packing

Con: 42 μg/150 μl

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Species specificity:
human, dog, guinea pig

Positive WB detected in:
human placenta tissue, human liver tissue

Recommended dilution:
WB : 1:200-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
Fc fragment of IgG, receptor, transporter, alpha

Calculated molecular weight:
40 kDa

Observed molecular weight:
35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FCGRT

Synonyms
alpha chain, FCGRT, FCRN, Neonatal Fc receptor
Background

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).


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