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FGFR2 (Fibroblast growth factor receptor 2) is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis. Ligand binding leads to the activation of several signaling pathway, such as RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. The modifications of FGFR2, including glycosylation, phosphorylation and ubiquitination, show a general accurance. A variety of studies suggest that FGFR may involve in many diseases, such as Craniosynostosis, Jackson-Weiss syndrome, Pfeiffer syndrome, Antley-Bixler syndrome, without genital anomalies or disordered steroidogenesis and so on.