FGFR2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 25895-1-AP

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Freight/Packing

Con: 43 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fibroblast growth factor receptor 2

Calculated molecular weight:
709aa,79 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FGFR2

Synonyms
BEK, BFR 1, CD332, CEK3, CFD1, ECT1, FGFR 2, FGFR2, FLJ98662, JWS, K SAM, KGFR, KSAM, TK14, TK25
Background

FGFR2 (Fibroblast growth factor receptor 2) is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis. Ligand binding leads to the activation of several signaling pathway, such as RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. The modifications of FGFR2, including glycosylation, phosphorylation and ubiquitination, show a general accurance. A variety of studies suggest that FGFR may involve in many diseases, such as Craniosynostosis, Jackson-Weiss syndrome, Pfeiffer syndrome, Antley-Bixler syndrome, without genital anomalies or disordered steroidogenesis and so on.


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