FOXO4 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 19121-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
human heart tissue, mouse heart tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
forkhead box O4

Calculated molecular weight:
54 kDa

Observed molecular weight:
45-48kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FOXO4

Synonyms
AFX, AFX1, forkhead box O4, Forkhead box protein O4, FOXO4, MLLT7
Background

FOXO4, also named as AFX, AFX1 and MLLT7, is a transcription factor which involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.FOXO down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. The antiboay can recognize isoform 1 and isoform Zeta of FOXO4.


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