YF488-conjugated FUS/TLS Antibody 0 Publications

Rabbit Polyclonal| Catalog number: YF488-11570

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Freight/Packing

Con: 105 μg/150 μl

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Tested Applications

Applications:
ELISA, IF
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Species specificity:
human, mouse, rat

Positive IF detected in:
HepG2 cells,

Recommended dilution:
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS buffer with 50% glycerol, pH7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fusion (involved in t(12;16) in malignant liposarcoma)

Calculated molecular weight:
75 kDa

Observed molecular weight:
75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FUS

Synonyms
75 kDa DNA pairing protein, FUS, FUS1, Oncogene FUS, Oncogene TLS
Background

FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration[PMID: 22640227]. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U)[PMID: 22640227]. This antibody is a rabbit polyclonal antibody raised against an internal region of human FUS. This antibody is conjugated with YF488, Ex/Em 488 nm/515 nm.


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