GDI2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60078-1-Ig |CloneNo.: 4B8F3

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Hepg2 cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human liver cancer tissue

Positive IF detected in:
MCF-7 cells, Hela cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
GDP dissociation inhibitor 2

Calculated molecular weight:
47 kDa

Observed molecular weight:
46 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GDI2

Synonyms
FLJ16452, FLJ37352, GDI 2, GDI2, GDP dissociation inhibitor 2, Rab GDI beta, RABGDIB
Background

GDP dissociation inhibitors (GDIs) are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, GDIs can bind and release GDP-bound Rab proteins from membranes. Two GDI proteins towards different Rab proteins have been identified. GDI1 interacts with almost all of the Rab proteins, while GDI2 interacts with Rabll but not Rab3A. GDI2 distributes ubiquitously, displaying a membrane bound location in perinuclear regions of cells. GDI-2 was thought to be involved in cellular response to insulin. It electrophoreses as a 46kd protein in SDS-PAGE. (PMID: 7929030; PMID: 19570034). This antibody can bind both GDIs for the close sequences.


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