GNE Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 25079-1-AP

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Freight/Packing

Con: 59 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human kidney tissue, human kidney tissue, human placenta tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

Calculated molecular weight:
722aa,79 kDa

Observed molecular weight:
79 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GNE

Synonyms
DMRV, GLCNE, GNE, IBM2, ManAc kinase, NM, Uae1, UDP GlcNAc 2 epimerase
Background

The bifunctional enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) is essential for early embryonic development and catalyzes the rate limiting step in sialic acid biosynthesis. It plays an important role in neuronal cell and brain development, and is strongly involved in cardiac tissue and skeletal muscle early survival and organization.. This protein has 5 isoforms produced by alternative splicing.


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