HB9 Polyclonal antibody

HB9 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 20975-1-AP

Synonyms

HB9, HLXB9, Homeobox protein HB9, HOXHB9, MNX1, SCRA1



Tested Applications

Positive WB detected inmouse spleen tissue, mouse liver tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

20975-1-AP targets HB9 in WB, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name motor neuron and pancreas homeobox 1
Calculated Molecular Weight 41 kDa
Observed Molecular Weight 45-50 kDa
GenBank Accession NumberNM_005515
Gene Symbol MNX1
Gene ID (NCBI) 3110
RRIDAB_2878779
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Motor neuron and pancreas homeobox (MNX1) is a homologous box transcription factor that promotes motor neuron differentiation and pancreatic development. MNX1 knockout in mice indicated that only the early expression of MNX1 is associated with the formation of pancreatic buds, and MNX1 is expressed in late β cells and associated with β cell maturation . MNX1 has the ability to induce endocrine progenitor cells to differentiate into β cells and inhibit their ability to differentiate into α cells, thereby maintaining the balance between α and β cells. In addition, the association between MNX1 gene mutations and Currarino syndrome has also been demonstrated. The Currarino syndrome phenotype caused by a MNX1 mutations was demonstrated to be a result of haploinsufficiency . A recent study also indicated that MNX1 may be an oncogene in prostate cancer (PMID: 30066929).

Protocols

Product Specific Protocols
WB protocol for HB9 antibody 20975-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols