HDAC4 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 17449-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 32 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HEK-293 cells, HeLa cells, Jurkat cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human kidney tissue, human cervical cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
histone deacetylase 4

Calculated molecular weight:
972aa,106 kDa

Observed molecular weight:
119-140 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HDAC4

Synonyms
HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288
Background

HDAC4, also named as HDACA, belongs to the histone deacetylase family. HDAC4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC4. The calcualted molecular weight of HDAC4 is 106 kDa, but modified HDAC4 is about 140kDa.


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