HGD Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 16465-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human liver tissue, HeLa cells

Positive IHC detected in:
human liver tissue

Recommended dilution:
WB : 1:500-1:2400
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
homogentisate 1,2-dioxygenase (homogentisate oxidase)

Calculated molecular weight:
37 kDa;50 kDa

Observed molecular weight:
50kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HGD

Synonyms
AKU, FLJ94126, HGD, HGO, Homogentisate 1,2 dioxygenase, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase
Background

Homogentisate1,2-dioxygenase (HGD), also named as HGO, is a mononuclear Fe(II)-dependent oxygenase that catalyzes the third step in the pathway for the catabolism of tyrosine, the conversion of homogentisate (HG) to maleylacetoacetate (MAA) and it can exsit as a dimer or trimer(PMID:14678794). HGD consists of a single type of subunit with no intermolecular disulfide bridges and requires Fe2+ as a cofactor(PMID: 7705358). Defects in HGD are the cause of alkaptonuria (AKU)(PMID:10594001).


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