IRT1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 51096-1-AP

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Freight/Packing

Con: 0 μg/150 μl

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Tested Applications

Applications:
ELISA
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Species specificity:
human

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
allograft inflammatory factor 1

Calculated molecular weight:
17 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AIF1

Synonyms
AIF 1, AIF1, G1, IBA1, IRT 1, Protein G1
Background

AIF1, also named as G1, IBA1 and daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. It may play a role in macrophage activation and function. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes.


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