ICMT Polyclonal antibody

ICMT Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

ELISA

Conjugate

Unconjugated

Cat no : 18983-1-AP

Synonyms

HSTE14, ICMT, MST098, MSTP098, PCCMT, PCMT, PPMT



Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

18983-1-AP targets ICMT in ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name isoprenylcysteine carboxyl methyltransferase
Calculated Molecular Weight 32 kDa
GenBank Accession NumberNM_012405
Gene Symbol ICMT
Gene ID (NCBI) 23463
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

ICMT, also named as PCCMT and PPMT, belongs to the isoprenylcysteine O-methyltransferase family. ICMT is the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. It localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. It is ubiquitously expressed. It expressed at higher levels in the cerebellum and putamen than in other brain regions and abundant expression seen in the Purkinje cells and pontine neurons.