IKBKB Antibody 0 Publications

Mouse Monoclonal| Catalog number: 65036-1-Ig

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Freight/Packing

Con: 100 μg/150 μl

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Tested Applications

Applications:
ELISA, IHC
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Species specificity:
human, mouse

Positive IHC detected in:
bladder carcinoma tissue

Recommended dilution:
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Antigen affinity purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Recombinant Protein

Full name:
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Calculated molecular weight:
756aa,81 kDa;256aa,29 kDa

Observed molecular weight:
87 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IKBKB

Synonyms
FLJ40509, I kappa B kinase 2, I kappa B kinase beta, IKBKB, IKK B, IKK beta, IKK2, IKKB, NFKBIKB
Background

KBKB, also named as IKKB, IKK2, NFKBIKB and IKK-B, belongs to the protein kinase superfamily, Ser/Thr protein kinase family and I-kappa-B kinase subfamily. IKBKB is a Serine kinase that plays an essential role in the NF-kappa-B signaling pathway. It acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. In addition to the NF-kappa-B inhibitors, IKBKB phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. It also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, IKBKB acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.


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