ING4-specific Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 16188-1-AP

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Freight/Packing

Con: 45 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, HEK-293 cells, HeLa cells, Jurkat cells, mouse colon tissue

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human brain tissue, human brain tissue, human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
inhibitor of growth family, member 4

Calculated molecular weight:
29 kDa

Observed molecular weight:
29-32 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ING4

Synonyms
ING4, Inhibitor of growth protein 4, my036, p29ING4
Background

ING4, also named as p29ING4, belongs to the ING family. It is a component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. It may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. ING4 can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. It may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). ING4 is a tumor suppressor gene that interacts with NFkB and represses its transcriptional activity. Several lines of evidence suggest that the tumor suppressor gene ING4, NFkB and its target genes matrix metalloproteases MMP-2, MMP-9 and urokinase plasminogen activator (u-PA) are critically involved in tumor invasion. This antibody is specifically against p29ING4.


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