ITM2C Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60095-1-Ig |CloneNo.: 2E8G11

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 143 μg/150 μl

Choose size:

Please visit your regions distributor:

Tested Applications

Applications:
ELISA, WB, IF
Application not tested? Please see our Guarantee




Species specificity:
human

Positive WB detected in:
A431 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
integral membrane protein 2C

Calculated molecular weight:
230aa,26 kDa;267aa,30 kDa

Observed molecular weight:
35kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ITM2C

Synonyms
BRICD2C, Cerebral protein 14, E25, E25C, integral membrane protein 2C, ITM2C, ITM3, PSEC0047, Transmembrane protein BRI3
Background

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.


Back
to top