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ITM2C Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60095-1-Ig |CloneNo.: 2E8G11

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Con: 143 μg/150 μl

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Tested Applications

Applications:
WB, IF, FC, ELISA
Application not tested? Please see our Guarantee


Images See all

ITM2C Antibody FC HepG2 cells 60095-1-Ig

1X10^6 HepG2 cells were stained with 0.20ug ITM2C antibody (60095-1-Ig, red) and control antibody (blue). Fixed with 90% MeOH

ITM2C Antibody IF HepG2 cells 60095-1-Ig

Immunofluorescent analysis of HepG2 cells using 60095-1-Ig(ITM2C antibody) at dilution of 1:50 and Rhodamine-Goat anti-Mouse IgG

Species specificity:
human
Positive WB detected in:
A431 cells
Positive IF detected in:
HepG2 cells
Positive FC detected in:
HepG2 cells
Recommended dilution:
WB : 1:500-1:1000
IF : 1:20-1:200

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Mouse
Purification method:
Caprylic acid/ammonium sulfate precipitation
Isotype:
IgG2a
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
ITM2C fusion protein Ag4409
Full name:
integral membrane protein 2C
Calculated molecular weight:
230aa,26 kDa;267aa,30 kDa
Observed molecular weight:
35 kDa
GenBank accession number:
BC025742
Gene ID (NCBI):
81618
Gene symbol
ITM2C
Synonyms
BRICD2C, Cerebral protein 14, E25, E25C, integral membrane protein 2C, ITM2C, ITM3, PSEC0047, Transmembrane protein BRI3

Background

The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.


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