Kininogen 1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66123-1-Ig |CloneNo.: 10E8D11

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Con: 141 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human heart tissue, human placenta tissue, human plasma tissue

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:5000-1:20000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
kininogen 1

Calculated molecular weight:
644aa,72 kDa

Observed molecular weight:
68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KNG1

Synonyms
BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1
Background

Kininogens are inhibitors of thiol proteases. Kininogen 1 plays important role in Kinin-kallikrein system. This gene is translated into High-molecular weight kininogen (HMWK) and low-molecular weight kininogen (LMWK) after alternative splicing. HMWK is produced by the liver together with prekallikrein. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. LMWK is produced locally by numerous tissues, and secreted together with tissue kallikrein.


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