pan Ras Antibody 3 Publications

Mouse Monoclonal| Catalog number: 60309-1-Ig |CloneNo.: 4H4G7

Featured Product KD/KO validated

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
fetal human brain tissue, HEK-293 cells, mouse brain tissue, Neuro-2a cells, rat brain tissue, ROS1728 cells

Positive IHC detected in:
human breast cancer tissue, human breast cancer tissue, human colon cancer tissue, human lung cancer tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:20000-1:50000
IHC : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Calculated molecular weight:
188aa,21 kDa

Observed molecular weight:
21 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
KRAS

Synonyms
C K RAS, c Ki ras, GTPase KRas, K Ras 2, K RAS2A, K RAS2B, K RAS4A, K RAS4B, KI RAS, KRAS, KRAS1, KRAS2, KRAS2B speicifc, Krasa, Krasb, NS3, pan Ras, RASK2
Background

The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras, and N-Ras) belong to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. K-Ras, H-Ras, and N-Ras have similar structure and sequences. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. The ras genes are ubiquitously expressed although mRNA analysis suggests different level expression in tissue. Mutations in each ras gene frequently were found in different tumors, suggesting their involvement in the development of specific neoplasia. This antibody can recognize K-Ras, H-Ras, and N-Ras.


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