LRP5 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 24899-1-AP

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Freight/Packing

Con: 31 μg/150 μl

Choose size:

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Species specificity:
human

Positive WB detected in:
HeLa cells

Positive IHC detected in:
human liver cancer tissue, human hepatocirrhosis tissue, human liver cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
low density lipoprotein receptor-related protein 5

Calculated molecular weight:
1615aa,179 kDa

Observed molecular weight:
200 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LRP5

Synonyms
BMND1, EVR1, EVR4, HBM, LR3, LRP 5, LRP5, LRP7, OPPG, OPS, OPTA1, VBCH2
Background

Low-density lipoprotein receptor-related protein 5 (LRP5) is a single-pass type I membrane protein with EGF-like and LDLR domains in the extracellular domain. LRP5 and LRP6 act as coreceptors with Frizzled for Wnt. The complex of Wnt-Fzd-LRP5-LRP6 triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. LRP5 plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in LRP5 gene.


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