MAGOH Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 12347-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
K-562 cells, HeLa cells, HL-60 cells, human brain tissue, K-562 cells, Raji cells

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mago-nashi homolog, proliferation-associated (Drosophila)

Calculated molecular weight:
146aa,17 kDa

Observed molecular weight:
17 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAGOH

Synonyms
MAGOH, MAGOHA, Protein mago nashi homolog
Background

MAGOH, belonging to the mago nashi family, is a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and a core EJC component Y14.


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