MGMT Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 17195-1-AP

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Freight/Packing

Con: 51 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells, MCF-7 cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human kidney tissue, human placenta tissue, human spleen tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
O-6-methylguanine-DNA methyltransferase

Calculated molecular weight:
22 kDa

Observed molecular weight:
22 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MGMT

Synonyms
MGMT
Background

MGMT is the primary vehicle for cellular removal of alkyl lesions from the O-6 position of guanine and the O-4 position of thymine. While key to the maintenance of genomic integrity, MGMT also removes damage induced by alkylating chemotherapies, inhibiting the efficacy of cancer treatment [PMID:23065697].MGMT is the primary mechanism for the removal of alkylation damage from the O-6 position of guanine [PMID: 17482892]. The O-6 position of guanine is one of several positions in DNA bases to which alkyl groups are attached in SN1 alkylation reactions, and this repair has been well-characterized in mammalian cells and via MGMT homologs in bacteria and Archaea.[PMID: 10767620]


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