MMP2 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66366-1-Ig |CloneNo.: 2B10D1

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, rat, mouse, pig

Positive WB detected in:
HepG2 cells, human heart tissue, human placenta tissue, MCF-7 cells, pig heart tissue, rat heart tissue

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:1000-1:6000
IHC : 1:150-1:600

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Calculated molecular weight:
72 kDa

Observed molecular weight:
55-74 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MMP2

Synonyms
72 kDa gelatinase, 72 kDa type IV collagenase, CLG4, CLG4A, Gelatinase A, Matrix metalloproteinase 2, MMP 2, MMP II, MMP2, MONA, TBE 1
Background

MMP2, also named as CLG4A, Gelatinase Am, TBE-1 and PEX, belongs to the peptidase M10A family. It is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. MMP2 contributes to myocardial oxidative stress by regulating the activity of GSK3beta. It cleaves GSK3beta in vitro. MMP2 can be cleaved into PEX chain(~60kd).Western blot analysis showed that the 72 kDa and 62 kDa proteinase activities were pro-MMP2 and the active enzyme,respectively(PMID:11112697).


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